Pathogenesis of sjogrens syndrome role of sphingosine 1. Sjogren s syndrome ss is a systemic autoimmune disease that has several oral manifestations, with reduced salivary flow being the most prevalent. It is characterized by dysfunction and destruction of the exocrine glands associated with lymphocytic infiltrates and immunological hyperreactivity. Sjogren s showgrins syndrome is a disorder of your immune system identified by its two most common symptoms dry eyes and a dry mouth.
Despite extensive molecular, histological and clinical studies, the underlying cause of ss and its pathogenesis remains unknown. In broad terms, pathogenesis is multifactorial, where several steps are necessary to establish the disease. Despite this, its exact aetiology and pathogenesis is still unclear. Sjogrens syndrome is a common autoimmune disease that presents with sicca symptoms and extraglandular features. Sjogrens syndrome ss is a chronic autoimmune disease characterized by the lymphocytic in ltration of salivary and lacrimal glands leading to xerostomia and keratoconjunctivitis sicca. Primary sjogrens syndrome is an autoimmune disorder characterized by lymphocytic infiltrates and destruction of the salivary and lachrymal glands and systemic production of autoantibodies to the ribonucleoprotein particles ssaro and ssbla. The vascularity and secretory function of exocrine glands affected in sjogrens syndrome are innervated by the sympathetic and parasympathetic branches of the ans. Sjogrens syndrome definition of sjogrens syndrome by. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
Salivary and lacrimal glands are the most affected, thus leading to mouth and eye dryness. Abstract sjogrens syndrome is a chronic autoimmune disease that affects many. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. Autonomic nervous system ans abnormalities are common in sjogrens syndrome 28,29,30,31 and may play an etiologic role in its pathogenesis. Epidemiology and pathogenesis of sjogrens syndrome. Pdf sjogrens syndrome is a chronic inflammatory disease of the lacrimal and salivary gland with subsequent keratoconjunctivitis sicca and. Pathogenesis of sjogrens syndrome pubmed central pmc. Pathogenesis the pathogenesis of sjogren syndrome is obscure. Primary sjogren s syndrome pss is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. Sjogrens syndrome is an autoimmune disorder that damages moistureproducing glands, making it difficult to produce saliva and tears. The immune factors involved in the pathogenesis, diagnosis, and.
Sjogrens syndrome ss is a chronic autoimmune disease that classically affects the lacrimal and salivary glands resulting in dry eyes and dry mouth and can affect almost any organ system in the body including the lungs, kidney, and central nervous system. Sjogrens syndrome ss is a systemic, autoimmune disorder characterized by salivary insufficiency and lymphocytic infiltration of the exocrine glands. Pathophysiology of sjogrens syndrome sciencedirect. Sjogrens syndrome is considered an autoimmune disease characterized by chronic inflammation involving the exocrine glands. Sjogrens syndrome synonyms, sjogrens syndrome pronunciation, sjogrens syndrome translation, english dictionary definition of sjogrens syndrome. It is characterized by dysfunction and destruction of the exocrine glands associated with lymphocytic infiltrates and immunological. Sjogrens syndrome ss is a relatively common systemic autoimmune disease characterized by. Sjogrens syndrome ss is a chronic autoimmune disorder. In sjogren s syndrome, the mucous membranes and moisturesecreting glands of your eyes and mouth are.
Reviewing primary sjogrens syndrome international journal. Primary sjogrens syndrome ss is an autoimmune disease characterized by inflammatory mononuclear cell infiltration and destruction of epithelial cells of. Autoimmunity, sjogrens syndrome, antibodies rola, antimuscarinic. This process leads to sicca syndrome, which is the combination of dryness of the eyes, oral cavity, pharynx, larynx andor vagina. Sjogrens syndrome sjs is a chronic autoimmune disorder characterized by immune cell infiltration and progressive injury to the salivary and lacrimal glands.
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